Cost-Effectiveness of Three Poliovirus Immunization Schedules in Shanghai, China

Cost-Effectiveness of Three Poliovirus Immunization Schedules in Shanghai, China

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In Shanghai, China, a polio immunization schedule of four inactivated polio vaccines (IPV) has been implemented click here since 2020, replacing the schedules of a combination of two IPVs and two bivalent live attenuated oral polio vaccines (bOPV), and four trivalent live attenuated oral polio vaccines (tOPV).This study aimed to assess the cost-effectiveness of these three schedules in infants born in 2016, in preventing vaccine-associated paralytic poliomyelitis (VAPP).We performed a decision tree model and estimated incremental cost-effectiveness ratio (ICER).Compared to the four-tOPV schedule, the two-IPV-two-bOPV schedule averted 1.2 VAPP cases and 16.

83 disability-adjusted life years (DALY) annually; while the four-IPV schedule averted 1.35 VAPP cases and 18.96 DALY annually.Consequently, ICERVAPP and ICERDALY were substantially high for two-IPV-two-bOPV (CNY 12.96 million and 0.

93 million), and four-IPV (CNY 21.24 million and 1.52 ivoryjinelle.com million).Moreover, net monetary benefit of the two-IPV-two-bOPV and four-IPV schedules was highest when the cost of IPV was hypothesized to be less than CNY 23.75 or CNY 9.

11, respectively, and willingness-to-pay was hypothesized as CNY 0.6 million in averting one VAPP-induced DALY.IPV-containing schedules are currently cost-ineffective in Shanghai.They may be cost-effective by reducing the prices of IPV, which may accelerate polio eradication in Chinese settings.